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Literature summary for 7.4.2.5 extracted from

  • Demirel, O.; Bangert, I.; Tampé, R.; Abele, R.
    Tuning the cellular trafficking of the lysosomal peptide transporter TAPL by its N-terminal domain (2010), Traffic, 11, 383-393.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HeLa cells Homo sapiens
expressed in MEF cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
orthovanadate
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Homo sapiens 5764
-
membrane
-
Homo sapiens 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
20000
-
TMD0 subunit Homo sapiens
60000
-
TAPL core complex Homo sapiens
70000
-
wild-type Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
Homo sapiens
-
HeLa cell
-
Homo sapiens
-

Subunits

Subunits Comment Organism
homodimer dissected in TMD0 (residues 1-142), containing a C-terminal myc-tag, and the core complex (residues 143-766), which consists of the cytosolic linker L0. Core-TAPL is essential and sufficient for peptide transport Homo sapiens

Synonyms

Synonyms Comment Organism
ABC transport
-
Homo sapiens
ABCB9
-
Homo sapiens
ATP-binding cassette transport
-
Homo sapiens
complex TAPL
-
Homo sapiens
TAPL
-
Homo sapiens
transporter associated with antigen processing-like
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens