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Literature summary for 7.4.2.5 extracted from

  • Elliott, A.M.; Al-Hajj, M.
    ABCB8 mediates doxorubicin resistance in melanoma cells by protecting the mitochondrial genome (2009), Mol. Cancer Res., 7, 79-87.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information knockdown of the ABC transporter enzyme in WM793B cells by shRNA leads to increases the sensitivity of cells to doxorubicin and reduces the cell survival, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial membrane
-
Homo sapiens 31966
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MDA-MB-435 cell
-
Homo sapiens
-
melanoma cell
-
Homo sapiens
-
WM-793B cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + peptide/in
-
Homo sapiens ADP + phosphate + peptide/out
-
?

Synonyms

Synonyms Comment Organism
ABCB8
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens