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Literature summary for 7.4.2.5 extracted from
- Modulation of the antigenic peptide transporter TAP by recombinant antibodies binding to the last five residues of TAP1 (2007), J. Mol. Biol., 369, 95-107.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| recombinant baculovirus, encoding human TAP1 and TAP2, is used for infection of Sf9 cells, used for the peptide transport assay | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Fv fragment of the monoclonal antibody mAb148.3 | Fv binding to the C terminus of TAP1 | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + peptide/in | Homo sapiens | - |
ADP + phosphate + peptide/out | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + peptide/in | - |
Homo sapiens | ADP + phosphate + peptide/out | - |
? | |
| ATP + H2O + RRYQNSTCL/in | substrate in peptide transport assay, fluorescein coupled via a cyteine residue | Homo sapiens | ADP + phosphate + RRYQNSTCL/out | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | TAP1, TAP2 | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| peptide-transporting ATPase | - |
Homo sapiens |
| TAP | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 32 | - |
peptide transport assay | Homo sapiens |
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