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Literature summary for 7.4.2.5 extracted from
- The first N-terminal transmembrane helix of each subunit of the antigenic peptide transporter TAP is essential for independent tapasin binding (2006), FEBS Lett., 580, 4091-4096.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| a set of N-terminally truncated human TAP variants are generated, PCR products are cloned into the vector pFASTBac Dual for expression in the Baculovirus system | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| coreTAP1 | mutant, delta2-122 | Homo sapiens |
| coreTAP2 | mutant, delta2-122 | Homo sapiens |
| DELTAN1-2TAP1 | mutant, delta2-89 | Homo sapiens |
| DELTAN1-2TAP2 | mutant, delta2-44 | Homo sapiens |
| DELTAN1-3TAP1 | mutant, delta2-132 | Homo sapiens |
| DELTAN1TAP1 | mutant, delta2-44 | Homo sapiens |
| DELTAN1TAP2 | mutant, delta2-44 | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum membrane | - |
Homo sapiens | 5789 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + peptide/in | Homo sapiens | - |
ADP + phosphate + peptide/out | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + peptide/in | - |
Homo sapiens | ADP + phosphate + peptide/out | - |
? | |
| ATP + H2O + RRYQNSTCL/in | peptide transport assay, fluorescein is coupled via the cysteine | Homo sapiens | ADP + phosphate + RRYQNSTCL/out | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | TAP1, TAP2 | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| peptide-transporting ATPase | - |
Homo sapiens |
| TAP | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 32 | - |
peptide transport assay | Homo sapiens |
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Release 2023.1 (January 2023)
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