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Literature summary for 7.4.2.12 extracted from
- TcyR regulates L-cystine uptake via the TcyABC transporter in Streptococcus mutans (2012), FEMS Microbiol. Lett., 328, 114-121 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| DL-cystathionine | strongly inhibited by DL-cystathionine | Streptococcus mutans |  |
| L-cysteine | moderately inhibited by L-cysteine | Streptococcus mutans | |
| L-djenkolic acid | strongly inhibited by L-djenkolic acid | Streptococcus mutans | |
| additional information | not inhibited by FeSO4, L-arginine, L-glutamine, L-glutamate, L-leucine, and L-methionine | Streptococcus mutans | |
| S-methyl-L-cysteine | moderately inhibited by S-methyl-L-cysteine | Streptococcus mutans | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + L-cystine-[cystine-binding protein](side 1) | Streptococcus mutans | - |
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1) | - |
? | |
| ATP + H2O + L-cystine-[cystine-binding protein](side 1) | Streptococcus mutans UA159 | - |
ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1) | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptococcus mutans | - |
- |
- |
| Streptococcus mutans UA159 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + L-cystine-[cystine-binding protein](side 1) | - |
Streptococcus mutans | ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1) | - |
? | |
| ATP + H2O + L-cystine-[cystine-binding protein](side 1) | - |
Streptococcus mutans UA159 | ADP + phosphate + L-cystine(side 2) + [cystine-binding protein](side 1) | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cystine ABC transporter | - |
Streptococcus mutans |
| TcyABC transporter | - |
Streptococcus mutans |
| TcyB | - |
Streptococcus mutans |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Streptococcus mutans | the transcriptional regulator TcyR negatively regulates the expression of the enzyme | down |
| Streptococcus mutans | enzyme expression is upregulated under cystine starvation and by the transcriptional activator CysR | up |
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