Literature summary for 7.4.2.1 extracted from

Kraidlova, L.; Van Zeebroeck, G.; Van Dijck, P.; Sychrova, H.
The Candida albicans GAP gene family encodes permeases involved in general and specific amino acid uptake and sensing (2011), Eukaryot. Cell, 10, 1219-1229.

Search for more literature for 7.4.2.1

Cloned(Commentary)

Cloned (Comment)	Organism
genes CaGap1-CaGap6, phylogenetic analysis, expression in Saccharomyces cerevisiae	Candida albicans

Organism

Organism	UniProt	Comment	Textmining
Candida albicans	-	six genes CaGap1-CaGap6	-

Synonyms

Synonyms	Comment	Organism
GAP1	-	Candida albicans
general amino acid permease	-	Candida albicans

General Information

General Information	Comment	Organism
evolution	the enzyme belongs to the GAP gene family	Candida albicans
physiological function	Candida albicans Gap2, CaGap2, is the true orthologue of Saccharomyces cerevisiae Gap1, which not only mediates the uptake of most amino acids but also functions as a receptor for the activation of protein kinase A, as it transports all tested amino acids. The other CaGap proteins have narrower substrate specificities though CaGap1 and CaGap6 transport several structurally unrelated amino acids. CaGap1, CaGap2, and CaGap6 also function as sensors, e.g. for methionine. CaGap permeases communicate to the intracellular signal transduction pathway	Candida albicans

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Release 2023.1 (January 2023)