Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ArsD | arsenic metallochaperone ArsD delivers As(III) to the ArsA ATPase, the catalytic subunit of the ArsAB pump. ArsD binds one arsenic per monomer coordinated with the three sulfur atoms of Cys12, Cys13 and Cys18, modeling of ArsD with and without bound As(III), overview. For analysis of metallo chaperone activity a recombinant truncated form, ArsD109, is used | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + antimonite/in | Saccharomyces cerevisiae | - |
ADP + phosphate + antimonite/out | - |
? | |
ATP + H2O + arsenite/in | Saccharomyces cerevisiae | - |
ADP + phosphate + arsenite/out | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + antimonite/in | - |
Saccharomyces cerevisiae | ADP + phosphate + antimonite/out | - |
? | |
ATP + H2O + arsenite/in | - |
Saccharomyces cerevisiae | ADP + phosphate + arsenite/out | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ArsAB pump | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
additional information | for arsenite transport, metallated ArsD interacts with and transfers As(III) to ArsA during catalysis, when the ATPase cycles between open to closed conformations, structure and ArsD-ArsA interaction analysis, docking of ArsD and ArsA and modeling, overview | Saccharomyces cerevisiae |