Cloned (Comment) | Organism |
---|---|
overexpression of Pit-1 in immortalized human aortic smooth muscle cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | smooth muscle cells expressing small interfering RNA show decreased Pit-1 mRNA and protein levels and reduced sodium-dependent phosphate transport activity compared with the control transduced cells, phosphate-induced smooth muscle cell calcification is significantly inhibited in smooth muscle cell-siRNA, and the siRNA-cells are not less susceptible to cell death than cells containing normal levels of Pit-1, overexpression of murine wild-type Pit-1 restores phosphate uptake and phosphate-induced calcification in human Pit-1 deficient cells, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + phosphate/out | Homo sapiens | Pit-1 is required for elevated phosphate-induced osteogenic gene expression in human smooth muscle cells, role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification, overview | ADP + phosphate + phosphate/in | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
vascular smooth muscle cell | expression of Pit-1 and Pit-2, Pit-1 is not a component of matrix vesicles or apoptotic bodies, expression analysis, Pit-1 is the predominant sodium-dependent phosphate cotransporter, overview | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + phosphate/out | - |
Homo sapiens | ADP + phosphate + phosphate/in | - |
? | |
ATP + H2O + phosphate/out | Pit-1 is required for elevated phosphate-induced osteogenic gene expression in human smooth muscle cells, role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification, overview | Homo sapiens | ADP + phosphate + phosphate/in | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PiT-1 | - |
Homo sapiens |
sodium-dependent phosphate cotransporter | - |
Homo sapiens |
type III sodium-dependent phosphate cotransporter | - |
Homo sapiens |