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Literature summary for 7.2.4.5 extracted from
- Substrate stereochemistry of the biotin-dependent sodium pump glutacoynl-CoA decarboxylase from Acidaminococcus fermentans (1986), Eur. J. Biochem., 156, 259-263.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| biotin | biotinyl enzyme | Acidaminococcus fermentans |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutaconyl-CoA + Na+[side 1] | Acidaminococcus fermentans | - |
but-2-enoyl-CoA + CO2 + Na+[side 2] | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Acidaminococcus fermentans | - |
ATCC 25085 | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| (2E)-4-carboxybut-2-enoyl-CoA + Na+[side 1] = (2E)-but-2-enoyl-CoA + CO2 + Na+[side 2] | stereochemistry | Acidaminococcus fermentans |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-carboxybut-2-enoyl-CoA + Na+[side 1] | - |
Acidaminococcus fermentans | but-2-enoyl-CoA + CO2 + Na+[side 2] | - |
? | |
| glutaconyl-CoA + Na+[side 1] | - |
Acidaminococcus fermentans | but-2-enoyl-CoA + CO2 + Na+[side 2] | - |
? | |
| additional information | enzyme catalyzes a 3H exchange of [2,4,4-3H]glutaconate with water when acetyl-CoA is present | Acidaminococcus fermentans | ? | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| biotin | biotinyl enzyme | Acidaminococcus fermentans | |
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