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Literature summary for 7.2.4.5 extracted from
- The sodium pump glutaconyl-CoA decarboxylase from Acidaminococcus fermentans. Specific cleavage by n-alkanols (1986), Eur. J. Biochem., 156, 251-257.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| biotin | Km: 40 mM | Acidaminococcus fermentans |  |
| biotin | biotinyl enzyme | Acidaminococcus fermentans | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | with increasing chain length, sodium ions prevent inactivation, Li+ is ten times less effective than Na+ | Acidaminococcus fermentans |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 30000 | - |
x * 120000, alpha, biotin carrier + x * 60000, beta, carboxytransferase, carboxylase + x * 30000, gamma, sodium pump, SDS-PAGE | Acidaminococcus fermentans |
| 60000 | - |
x * 120000, alpha, biotin carrier + x * 60000, beta, carboxytransferase, carboxylase + x * 30000, gamma, sodium pump, SDS-PAGE | Acidaminococcus fermentans |
| 120000 | - |
x * 120000, alpha, biotin carrier + x * 60000, beta, carboxytransferase, carboxylase + x * 30000, gamma, sodium pump, SDS-PAGE | Acidaminococcus fermentans |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutaconyl-CoA + Na+[side 1] | Acidaminococcus fermentans | - |
but-2-enoyl-CoA + CO2 + Na+[side 2] | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Acidaminococcus fermentans | - |
ATCC 25085 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-carboxybut-2-enoyl-CoA + Na+[side 1] | - |
Acidaminococcus fermentans | but-2-enoyl-CoA + CO2 + Na+[side 2] | - |
? | |
| glutaconyl-CoA + Na+[side 1] | - |
Acidaminococcus fermentans | but-2-enoyl-CoA + CO2 + Na+[side 2] | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 120000, alpha, biotin carrier + x * 60000, beta, carboxytransferase, carboxylase + x * 30000, gamma, sodium pump, SDS-PAGE | Acidaminococcus fermentans |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| biotin | Km: 40 mM | Acidaminococcus fermentans | |
| biotin | biotinyl enzyme | Acidaminococcus fermentans | |
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Release 2023.1 (January 2023)
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