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Literature summary for 7.2.2.9 extracted from

  • Miyayama, T.; Hiraoka, D.; Kawaji, F.; Nakamura, E.; Suzuki, N.; Ogra, Y.
    Roles of COMM-domain-containing 1 in stability and recruitment of the copper-transporting ATPase in a mouse hepatoma cell line (2010), Biochem. J., 429, 53-61.
    View publication on PubMed
Search for more literature for 7.2.2.9

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Hepa 1-6 cells Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasmic vesicle COMM-domain-containing 1 maintains the amount of Atp7b and facilitates recruitment of the enzyme from cytoplasmic vesicles to the trans-Golgi network membrane Mus musculus 31410
-
Golgi apparatus COMM-domain-containing 1 maintains the amount of Atp7b and facilitates recruitment of the enzyme from cytoplasmic vesicles to the trans-Golgi network membrane Mus musculus 5794
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cu+/in Mus musculus
-
 ADP + phosphate + Cu+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q64446
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEPA 1-6 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + cisplatin/in
-
 Mus musculus ADP + phosphate + cisplatin/out
-
 ?
ATP + H2O + Cu+/in
-
 Mus musculus ADP + phosphate + Cu+/out
-
 ?

Synonyms

Synonyms Comment Organism
ATP-dependent copper transporter 7beta
-
 Mus musculus
ATP7B
-
 Mus musculus
copper transporting ATPase
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus COMM-domain-containing 1 knockdown reduces the expression of Atp7b, and abolishes the relocation of Atp7b back from the periphery to the trans-Golgi network membrane down