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Literature summary for 7.2.2.9 extracted from

  • Hassani, B.K.; Astier, C.; Nitschke, W.; Ouchane, S.
    CtpA, a copper-translocating P-type ATPase involved in the biogenesis of multiple copper-requiring enzymes (2010), J. Biol. Chem., 285, 19330-19337.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.9

Protein Variants

Protein Variants Comment Organism
additional information ctpA disruption mutants show a drastic decrease in both cbb3 and caa3 oxidase activities. Inactivation of ctpA results also in a decrease in the amount of the nitrous oxide reductase, NosZ. This pleiotropic phenotype can be partially rescued by excess copper in the medium Rubrivivax gelatinosus

Localization

Localization Comment Organism GeneOntology No. Textmining
inner membrane
-
 Bradyrhizobium japonicum
-
-
inner membrane
-
 Rhodobacter capsulatus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Bradyrhizobium japonicum
Mg2+ required Rubrivivax gelatinosus
Mg2+ required Rhodobacter capsulatus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cu2+/in Bradyrhizobium japonicum
-
 ADP + phosphate + Cu2+/out
-
 ?
ATP + H2O + Cu2+/in Rubrivivax gelatinosus
-
 ADP + phosphate + Cu2+/out
-
 ?
ATP + H2O + Cu2+/in Rhodobacter capsulatus
-
 ADP + phosphate + Cu2+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Bradyrhizobium japonicum
-
 gene ctpA or ccoI
-
Rhodobacter capsulatus
-
 gene ctpA or ccoI
-
Rubrivivax gelatinosus
-
 gene ctpA
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cu2+/in
-
 Bradyrhizobium japonicum ADP + phosphate + Cu2+/out
-
 ?
ATP + H2O + Cu2+/in
-
 Rubrivivax gelatinosus ADP + phosphate + Cu2+/out
-
 ?
ATP + H2O + Cu2+/in
-
 Rhodobacter capsulatus ADP + phosphate + Cu2+/out
-
 ?

Synonyms

Synonyms Comment Organism
CcoI
-
 Bradyrhizobium japonicum
CcoI
-
 Rhodobacter capsulatus
copper-translocating P-type ATPase
-
 Bradyrhizobium japonicum
copper-translocating P-type ATPase
-
 Rubrivivax gelatinosus
copper-translocating P-type ATPase
-
 Rhodobacter capsulatus
copper-translocating P1B-type ATPase
-
 Bradyrhizobium japonicum
copper-translocating P1B-type ATPase
-
 Rhodobacter capsulatus
CtpA
-
 Bradyrhizobium japonicum
CtpA
-
 Rubrivivax gelatinosus
CtpA
-
 Rhodobacter capsulatus

General Information

General Information Comment Organism
physiological function the enzyme is involved in the cbb3 assembly and in cbb3 oxidase biogenesis Bradyrhizobium japonicum
physiological function the enzyme is involved in the cbb3 assembly and in cbb3 oxidase biogenesis Rhodobacter capsulatus
physiological function the enzyme is involved only in the cbb3 assembly. CtpA is likely a copper transporter that supplies copper-requiring proteins in the membrane with this metal. Although CtpA shares significant sequence homologies with the homeostasis copper efflux P1B-type ATPases including the bacterial CopA and the human ATP7A and ATP7B, disruption of ctpA did not result in any sensitivity to excess copper. Thus, CtpA is not crucial for copper tolerance but is involved in the assembly of membrane and periplasmic copper enzymes in this bacterium Rubrivivax gelatinosus