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Literature summary for 7.2.2.9 extracted from

  • Hernandez, S.; Tsuchiya, Y.; Garcia-Ruiz, J.P.; Lalioti, V.; Nielsen, S.; Cassio, D.; Sandoval, I.V.
    ATP7B copper-regulated traffic and association with the tight junctions: copper excretion into the bile (2008), Gastroenterology, 134, 1215-1223.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi trans face copper excess shown to provoke massive download of ATP7B retained in the Golgi network into the bile canalicular membrane Homo sapiens
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-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cu2+/in Homo sapiens
-
ADP + phosphate + Cu2+/out
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P35670
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-

Source Tissue

Source Tissue Comment Organism Textmining
bile canaliculus cellular distribution of ATP7B, stable ATP7B pool localized to the tight junctions that seal the bile canaliculi shown Homo sapiens
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liver copper excretion into the bile Homo sapiens
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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microscopy and cell fractionation studies applied to study cellular distribution of ATP7B, profile of radio-labelled copper excretion into the bile measured, evidence of copper excretion by transcytosis across the hepatocyte and by paracellular transport throughout the tight junctions discussed Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cu2+/in
-
Homo sapiens ADP + phosphate + Cu2+/out
-
?
ATP + H2O + Cu2+/in correspondence between the site of ATP7B action and distribution and the pathways of copper disposal by the liver Homo sapiens ADP + phosphate + Cu2+/out
-
?

Synonyms

Synonyms Comment Organism
ATP7B
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Homo sapiens