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Literature summary for 7.2.2.9 extracted from

  • Hardman, B.; Michalczyk, A.; Greenough, M.; Camakaris, J.; Mercer, J.F.; Ackland, M.L.
    Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells (2007), Biochem. J., 402, 241-250.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.9

Activating Compound

Activating Compound Comment Organism Structure
Insulin increase of mRNA and protein levels of ATP7A Homo sapiens

Application

Application Comment Organism
medicine studies on copper deficiency during pregnancy, Menkes and Wilson disease Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-
membrane basolateral membrane Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cu2+/in Homo sapiens
-
 ADP + phosphate + Cu2+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P35670
-
-
Homo sapiens Q04656 ATP7A
-

Source Tissue

Source Tissue Comment Organism Textmining
JEG-3 cell
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
syncytiotrophoblast
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 effect of hormone treatment on expression analyzed by Western blot, indirect immunocytochemistry and real-time PCR, copper transport and accumulation, insulin and oestrogen increase ATP7A mRNA and protein levels and alter the localization of ATP7A towards the basolateral membrane in a copper-independent manner, insulin and oestrogen increase the transport of copper across basolateral membrane, model of insulin and oestrogen effect on ATP7A and ATP7B in the placenta Homo sapiens
additional information
-
 effect of hormone treatment on expression analyzed by Western blot, indirect immunocytochemistry and real-time PCR, copper transport and accumulation, levels of ATP7B decreased in response to insulin, protein shown to localize in a tight perinuclear region, corresponding decrease in copper efflux across the apical membrane, model of insulin and oestrogen effect on ATP7A and ATP7B in the human placenta Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cu2+/in
-
 Homo sapiens ADP + phosphate + Cu2+/out
-
 ?
ATP + H2O + Cu2+/in differential regulation of ATP7A and ATP7B by the hormones insulin and oestrogen in human placental cells Homo sapiens ADP + phosphate + Cu2+/out
-
 ?

Synonyms

Synonyms Comment Organism
ATP7A
-
 Homo sapiens
ATP7B
-
 Homo sapiens
Menkes copper-transporting ATPase
-
 Homo sapiens
MNK protein
-
 Homo sapiens
Wilson copper-transporting ATPase
-
 Homo sapiens
WND protein
-
 Homo sapiens