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Literature summary for 7.2.2.9 extracted from

  • Llanos, R.M.; Michalczyk, A.A.; Freestone, D.J.; Currie, S.; Linder, M.C.; Ackland, M.L.; Mercer, J.F.
    Copper transport during lactation in transgenic mice expressing the human ATP7A protein (2008), Biochem. Biophys. Res. Commun., 372, 613-617.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.9

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane basolateral membrane of mammary epithelial cells in lactating mice Mus musculus 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cu2+/in Mus musculus
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 ADP + phosphate + Cu2+/out
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q64430 ATP7A
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Mus musculus Q64446
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Source Tissue

Source Tissue Comment Organism Textmining
mammary epithelium ATP7A expressed in Mus musculus
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mammary gland ATP7A protein 10fold to 20fold higher in transgenic than in control mice Mus musculus
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mammary gland transgenic mice Mus musculus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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 copper concentration in the mammary gland reduced in transgenic mice, immunofluorescence analysis of mammary gland tissue, tissue copper concentration, mRNA levels of endogenous ATP7A and ATP7B and of ATP7B protein unaltered in mammary gland of transgenic mice, ATP7A plays a role in removing excess copper from mammary epithelial cells rather than supplying copper to milk Mus musculus
additional information
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 mRNA levels of endogenous ATP7B and of ATP7B protein unaltered in mammary gland of transgenic mice Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cu2+/in
-
 Mus musculus ADP + phosphate + Cu2+/out
-
 ?
ATP + H2O + Cu2+/in role of ATP7A in delivery of copper to milk using transgenic mice that over-express human ATP7A Mus musculus ADP + phosphate + Cu2+/out
-
 ?

Synonyms

Synonyms Comment Organism
ATP7A
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 Mus musculus
ATP7B
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 Mus musculus