Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 7.2.2.9 extracted from

  • Lutsenko, S.; LeShane, E.S.; Shinde, U.
    Biochemical basis of regulation of human copper-transporting ATPases (2007), Arch. Biochem. Biophys., 463, 134-148.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.9

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi trans face
-
 Homo sapiens
-
-
Golgi trans face trafficking from the trans-Golgi network to endocytic vesicles in response to various signals Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cu2+/in Homo sapiens
-
 ADP + phosphate + Cu2+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P35670
-
-
Homo sapiens Q04656 ATP7A
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 biochemical and structural characteristics of human copper-ATPase, unique sequence motifs in regulating ATP7A and ATP7B activity and trafficking, transmembrane organization and catalytic cycle, sequence and predicted folding of transmembrane portion, metal binding pockets of N-terminal domain and ATP-binding domain Homo sapiens
additional information
-
 biochemical and structural characteristics of human copper-ATPases, unique sequence motifs in regulating ATP7A and ATP7B activity and trafficking, dual role of copper-transporting ATPase ATP7B in hepatocyte, transmembrane organization and catalytic cycle, sequence and predicted folding of transmembrane portion, metal-binding pockets of N-terminal domain and ATP-binding domain Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cu2+/in
-
 Homo sapiens ADP + phosphate + Cu2+/out
-
 ?
ATP + H2O + Cu2+/in structural features and functional properties of ATP7A Homo sapiens ADP + phosphate + Cu2+/out
-
 ?
ATP + H2O + Cu2+/in structural features and functional properties of ATP7A and ATP7B Homo sapiens ADP + phosphate + Cu2+/out
-
 ?

Synonyms

Synonyms Comment Organism
ATP7A
-
 Homo sapiens
ATP7B
-
 Homo sapiens