Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 7.2.2.9 extracted from

  • Ravia, J.J.; Stephen, R.M.; Ghishan, F.K.; Collins, J.F.
    Menkes copper ATPase (Atp7a) is a novel metal-responsive gene in rat duodenum, and immunoreactive protein is present on brush-border and basolateral membrane domains (2005), J. Biol. Chem., 280, 36221-36227.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.9

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane ATP7A protein levels are increased in brush-border and basolateral membrane vesicles isolated from iron-defiocient rats Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cu2+/in Homo sapiens ATP7A is involved in copper loading observed during iron deficiency. Increased intestinal copper transport is of physiological relevance, as copper plays important roles in overall body iron homeostasis ADP + phosphate + Cu2+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q04656
-
-

Source Tissue

Source Tissue Comment Organism Textmining
duodenum ATP7A is present on apical domains of duodenal enterocytes in control rats and on brush-border and basolateral membrane domains in iron-deprived rats Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cu2+/in ATP7A is involved in copper loading observed during iron deficiency. Increased intestinal copper transport is of physiological relevance, as copper plays important roles in overall body iron homeostasis Homo sapiens ADP + phosphate + Cu2+/out
-
 ?

Synonyms

Synonyms Comment Organism
ATP7A
-
 Homo sapiens
Menkes copper ATPase
-
 Homo sapiens