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Literature summary for 7.2.2.9 extracted from

  • Hung, Y.H.; Layton, M.J.; Voskoboinik, I.; Mercer, J.F.; Camakaris, J.
    Purification and membrane reconstitution of catalytically active Menkes copper transporting P-type ATPase (MNK; ATP7A) (2007), Biochem. J., 401, 569-579.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.9

Cloned(Commentary)

Cloned (Comment) Organism
expression of Menkes disease protein with an N-terminal Glu-Glu tag in Sf9 cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0036
-
 ATP
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Cu+ formation of the vanadate-sensitive phosphoenzyme by purified Menkes diesease protein is activated by Cu+. Cu+ interacts with Menkes disease protein in a cooperative manner and with high affinity in the sub-micromolar range Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cu2+/in
-
 Homo sapiens ADP + phosphate + Cu2+/out
-
 ?

Synonyms

Synonyms Comment Organism
ATP7A
-
 Homo sapiens
Menkes copper transporting P-type ATPase
-
 Homo sapiens
MNK
-
 Homo sapiens