Literature summary for 7.2.2.9 extracted from

Harada, M.; Sakisaka, S.; Kawaguchi, T.; Kimura, R.; Taniguchi, E.; Koga, H.; Hanada, S.; Baba, S.; Furuta, K.; Kumashiro, R.; Sugiyama, T.; Sata, M.
Copper does not alter the intracellular distribution of ATP7B, a copper-transporting ATPase (2000), Biochem. Biophys. Res. Commun., 275, 871-876.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endosome	mainly localized in the late endosomes in both the steady and copper-loaded states. ATP7B translocates copper from the cytosol to the late endosomal lumen, thus participating in biliary copper excretion via lysosomes	Homo sapiens	5768	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + Cu2+/in	Homo sapiens	ATP7B translocates copper from the cytosol to the late endosomal lumen, thus participating in biliary copper excretion via lysosomes. Disturbed incorporation of copper into the late endosomal lumen from the cytosol by the mutated ATP7B is the main defect of Wilson's disease	ADP + phosphate + Cu2+/out	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + Cu2+/in	-	Homo sapiens	ADP + phosphate + Cu2+/out	-	?
ATP + H2O + Cu2+/in	ATP7B translocates copper from the cytosol to the late endosomal lumen, thus participating in biliary copper excretion via lysosomes. Disturbed incorporation of copper into the late endosomal lumen from the cytosol by the mutated ATP7B is the main defect of Wilson's disease	Homo sapiens	ADP + phosphate + Cu2+/out	-	?

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Release 2023.1 (January 2023)