Cloned (Comment) | Organism |
---|---|
cloning of the 5'-end of the Wilson disease gene ATP7B | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Cu2+/in | Homo sapiens | autosomal recessive Wilson disease is characterized by copper toxicity believed to result from the loss of ability to export copper from liver to bile and incorporate copper into ceruloplasmin in the liver. Mechanism of alternative splicing serves to regulate the amount of functional Wilson disease protein produced in brain, kidney and placenta | ADP + phosphate + Cu2+/out | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Cu2+/in | - |
Homo sapiens | ADP + phosphate + Cu2+/out | - |
? | |
ATP + H2O + Cu2+/in | autosomal recessive Wilson disease is characterized by copper toxicity believed to result from the loss of ability to export copper from liver to bile and incorporate copper into ceruloplasmin in the liver. Mechanism of alternative splicing serves to regulate the amount of functional Wilson disease protein produced in brain, kidney and placenta | Homo sapiens | ADP + phosphate + Cu2+/out | - |
? |