Literature summary for 7.2.2.8 extracted from

Petrov, E.; Menon, G.; Rohde, P.; Battle, A.; Martinac, B.; Solioz, M.
Xenon-inhibition of the MscL mechanosensitive channel and the CopB copper ATPase under different conditions suggests direct effects on these proteins (2018), PLoS ONE, 13, e0198110 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
xenon	inhibits CopB copper ATPase both when reconstituted into proteoliposomes and in a solubilized state	Enterococcus hirae

Organism

Organism	UniProt	Comment	Textmining
Enterococcus hirae	P05425	isoform CopB	-
Enterococcus hirae DSM 20160	P05425	isoform CopB	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.155	-	solubilized enzyme, presence of xenon, pH 6.5, 37°C	Enterococcus hirae
0.266	-	solubilized enzyme, presence of phospholipids and xenon, pH 6.5, 37°C	Enterococcus hirae
0.339	-	reconstituted enzyme, presence of xenon, pH 6.5, 37°C	Enterococcus hirae
0.541	-	reconstituted enzyme, pH 6.5, 37°C	Enterococcus hirae
0.976	-	solubilized enzyme, pH 6.5, 37°C	Enterococcus hirae
1.046	-	solubilized enzyme, presence of phospholipids, pH 6.5, 37°C	Enterococcus hirae

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + Cu+[side 1]	-	Enterococcus hirae	ADP + phosphate + Cu+[side 2]	-	?
ATP + H2O + Cu+[side 1]	-	Enterococcus hirae DSM 20160	ADP + phosphate + Cu+[side 2]	-	?

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Release 2023.1 (January 2023)