Literature summary for 7.2.2.8 extracted from

Meydan, S.; Klepacki, D.; Karthikeyan, S.; Margus, T.; Thomas, P.; Jones, J.E.; Khan, Y.; Briggs, J.; Dinman, J.D.; Vazquez-Laslop, N.; Mankin, A.S.
Programmed ribosomal frameshifting generates a copper transporter and a copper chaperone from the same gene (2017), Mol. Cell, 65, 207-219 .

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Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	Q59385	-	-

Synonyms

Synonyms	Comment	Organism
CopA	-	Escherichia coli

General Information

General Information	Comment	Organism
physiological function	the CopA chaperone is expressed in Escherichia coli from the same gene that encodes the transporter. Some ribosomes translating CopA undergo programmed frameshifting, terminate translation in the -1 frame, and generate the 70 aa-long polypeptide CopA(Z), which helps cells survive toxic copper concentrations. High efficiency of frameshifting is achieved by the combined stimulatory action of a slippery sequence, an mRNA pseudoknot, and the CopA nascent chain	Escherichia coli

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Release 2023.1 (January 2023)