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Literature summary for 7.2.2.8 extracted from
- The function of ATPase copper transporter ATP7B in intestine (2018), Gastroenterology, 154, 168-180.e5 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q64446 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| enterocyte | - |
Mus musculus | - |
| intestine | - |
Mus musculus | - |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | transporter ATP7B maintains a Cu gradient along the duodenal crypt-villus axis and buffers Cu levels in the cytosol of enterocytes, mediated by rapid Cu-dependent enlargement of ATP7B-containing vesicles and increased levels of ATP7B. Intestines of Atp7b-/- mice show reduced Cu storage pools in intestine, Cu depletion, accumulation of triglyceride-filled vesicles in enterocytes, mislocalization of apolipoprotein B, and loss of chylomicrons | Mus musculus |
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Release 2023.1 (January 2023)
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