Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P70705 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | - |
Rattus norvegicus | - |
vascular smooth muscle cell | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
ATP7A | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | ATP7A interacts with IQGAP1, a Rac1 and receptor tyrosine kinase binding scaffolding protein. In cultured rat aortic smooth muscle cells, PDGF stimulation rapidly promotes ATP7A association with IQGAP1 and Rac1 and their translocation to the lipid rafts and leading edge. ATP7A directly binds to NH2-terminal domain of IQGAP1. Both ATP7A or IQGAP1 depletion using siRNA significantly inhibits PDGF-induced vascular smooth muscle cell migration without additive effects | Rattus norvegicus |