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Literature summary for 7.2.2.8 extracted from

  • Ashino, T.; Kohno, T.; Sudhahar, V.; Ash, D.; Ushio-Fukai, M.; Fukai, T.
    Copper transporter ATP7A interacts with IQGAP1, a Rac1 binding scaffold protein role in PDGF-induced VSMC migration and vascular remodeling (2018), Am. J. Physiol. Cell Physiol., 315, C850-C862 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P70705
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Source Tissue

Source Tissue Comment Organism Textmining
aorta
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Rattus norvegicus
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vascular smooth muscle cell
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Rattus norvegicus
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Synonyms

Synonyms Comment Organism
ATP7A
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Rattus norvegicus

General Information

General Information Comment Organism
physiological function ATP7A interacts with IQGAP1, a Rac1 and receptor tyrosine kinase binding scaffolding protein. In cultured rat aortic smooth muscle cells, PDGF stimulation rapidly promotes ATP7A association with IQGAP1 and Rac1 and their translocation to the lipid rafts and leading edge. ATP7A directly binds to NH2-terminal domain of IQGAP1. Both ATP7A or IQGAP1 depletion using siRNA significantly inhibits PDGF-induced vascular smooth muscle cell migration without additive effects Rattus norvegicus