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Literature summary for 7.2.2.8 extracted from

  • Sudhahar, V.; Urao, N.; Oshikawa, J.; McKinney, R.D.; Llanos, R.M.; Mercer, J.F.; Ushio-Fukai, M.; Fukai, T.
    Copper transporter ATP7A protects against endothelial dysfunction in type 1 diabetic mice by regulating extracellular superoxide dismutase (2013), Diabetes, 62, 3839-3850.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
enzyme overexpression in transgenic mmice Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Mus musculus 16020
-

Organism

Organism UniProt Comment Textmining
Mus musculus Q64430
-
-
Mus musculus C57/BL6J Q64430
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
Mus musculus
-
blood vessel
-
Mus musculus
-
endothelium
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
ATP7A
-
Mus musculus
copper transporter
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus copper transporter ATP7A protein expression is significantly reduced in blood vessels from type 1 diabetes mellitus mice down
Mus musculus insulin treatment, but not high glucose, increases enzyme ATP7A expression in vascular smooth muscles cells up

General Information

General Information Comment Organism
malfunction role of extracellular superoxide dismutase SOD3 and ATP7A in endothelial dysfunction in type 1 diabetes mellitus. Type 1 diabetes mellitus-induced endothelial dysfunction and decrease of SOD3 activity are rescued in transgenic mice overexpressing the enzyme ATP7A, a copper transporter. Copper transporter ATP7A protein expression is significantly reduced in blood vessels from type 1 diabetes mellitus mice in part due to the insulin deficiency but not high glucose. Transgenic mice overexpressing ATP7A restore type 1 diabetes mellitus-induced impaired SOD3 activity and endothelial function by reducing superoxide levels Mus musculus
physiological function the enzyme ATP7A plays a critical role in delivering cofactor copper to extracellular superoxide dismutase SOD3 for its full activation Mus musculus