Protein Variants | Comment | Organism |
---|---|---|
Y196I | mutation in periplasmic biding protein, FbpA, greatly diminishes iron binding affinity, but has about 35% of wild-type transport activity | Haemophilus influenzae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ga3+ | exhibis toxicity to Escherichia coli expressing the enzyme | Haemophilus influenzae | |
additional information | not inhibitory: carbonyl cyanide m-chlorophenyl hydrazone | Haemophilus influenzae | |
sodium orthovanadate | - |
Haemophilus influenzae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0009 | - |
Fe3+ | 37°C, wild-type | Haemophilus influenzae | |
0.0012 | - |
Fe3+ | 37°C, mutant Y196I | Haemophilus influenzae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Haemophilus influenzae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Fe3+/out | high specificity for Fe3+ | Haemophilus influenzae | ADP + phosphate + Fe3+/in | - |
? | |
additional information | enzyme has high selectivity for trivalent metals, including Ga3+ and Al3+, over divalent metals | Haemophilus influenzae | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
hFbpABC transporter | - |
Haemophilus influenzae |