Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ceramide | mediates enzyme inhibition to about 60% by activating protein kinase A and protein kinase Czeta, that regulate ion transporter activities. Inhibition of the kinase reverses the inhibitory effect of ceramide on Na+-ATPase | Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Sus scrofa | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Na+/in | Sus scrofa | - |
ADP + phosphate + Na+/out | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | Na+-ATPase is inhibited by reversible phosphorylation through protein kinase A and protein kinase Czeta | Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Sus scrofa | - |
renal tubule | basolateral membranes of kidney proximal tubule cells | Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Na+/in | - |
Sus scrofa | ADP + phosphate + Na+/out | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Na+-ATPase | - |
Sus scrofa |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Sus scrofa |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Sus scrofa |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0001 | - |
pH 7.4, 37°C | Sus scrofa | ceramide |
General Information | Comment | Organism |
---|---|---|
additional information | Cer acts as a potent physiological modulator of the Na+-ATPase, participating in a regulatory network in kidney cells and counteracting the stimulatory effect of PKA via PKCzeta | Sus scrofa |
physiological function | the Na+-ATPase is involved in Na+ reabsorption in the kidney. Ouabain-insensitive Na+-ATPase is considered the fine tuner of cytosolic Na+, the selective key roles of ceramide under Na+-induced osmotic stress | Sus scrofa |