Application | Comment | Organism |
---|---|---|
pharmacology | lower concentration of [(dihydroindenyl)oxy]acetic acid should be used for evaluation of the activity of K+-Cl- cotranporter without affecting the activities of coexisting Na+,K+-ATPase and H+,K+-ATPase in cells | Sus scrofa |
pharmacology | lower concentration of [(dihydroindenyl)oxy]acetic acid should be used for evaluation of the activity of K+-Cl- cotranporter without affecting the activities of coexisting Na+,K+-ATPase and H+,K+-ATPase in cells | Canis lupus familiaris |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ouabain | - |
Canis lupus familiaris | |
Ouabain | - |
Sus scrofa | |
[(dihydroindenyl)oxy]acetic acid | DIOA | Canis lupus familiaris | |
[(dihydroindenyl)oxy]acetic acid | DIOA | Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Sus scrofa | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Canis lupus familiaris | - |
LLC-PK1 cell | in the membrane of porcine LLC-PK1 cells stably expressing rabbit gastric H+,K+-ATPase, [(dihydroindenyl)oxy]acetic acid inhibits activities of endogenous Na+,K+-ATPase | Sus scrofa | - |
Synonyms | Comment | Organism |
---|---|---|
Na+,K+-ATPase | - |
Sus scrofa |
Na+,K+-ATPase | - |
Canis lupus familiaris |
Na+-exporting ATPase | - |
Sus scrofa |
Na+-exporting ATPase | - |
Canis lupus familiaris |
P-type ATPase | - |
Sus scrofa |
P-type ATPase | - |
Canis lupus familiaris |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
Na+,K+-ATPase activity assay | Sus scrofa |
37 | - |
Na+,K+-ATPase activity assay | Canis lupus familiaris |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
Na+,K+-ATPase activity assay | Sus scrofa |
7.4 | - |
Na+,K+-ATPase activity assay | Canis lupus familiaris |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.053 | - |
- |
Canis lupus familiaris | [(dihydroindenyl)oxy]acetic acid | |
0.095 | - |
endogenous Na+,K+-ATPase | Sus scrofa | [(dihydroindenyl)oxy]acetic acid |