Literature summary for 7.2.2.21 extracted from

Maynaud, G.; Brunel, B.; Yashiro, E.; Mergeay, M.; Cleyet-Marel, J.C.; Le Quere, A.
CadA of Mesorhizobium metallidurans isolated from a zinc-rich mining soil is a P(IB-2)-type ATPase involved in cadmium and zinc resistance (2014), Res. Microbiol., 165, 175-189 .

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Organism

Organism	UniProt	Comment	Textmining
Mesorhizobium metallidurans	I4IY19	-	-
Mesorhizobium metallidurans STM 2683T	I4IY19	-	-

Synonyms

Synonyms	Comment	Organism
CadA1	-	Mesorhizobium metallidurans
heavy metal-translocating P-type ATPase 1	-	Mesorhizobium metallidurans

General Information

General Information	Comment	Organism
physiological function	a CadA-deleted strain fails to grow at high zinc concentrations (2 mM) and its growth is delayed at lower zinc concentrations. CadA is specifically induced in a dose-dependent manner by zinc and cadmium in in vitro conditions and into Anthyllis vulneraria nodules after Zn stress. Metal induction sensitivity is increased in the strain where CadA gene is deleted. Heterlogous expression in Escherichia coli confers resistance to Cd2+ to the clone	Mesorhizobium metallidurans

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Release 2023.1 (January 2023)