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Literature summary for 7.2.2.21 extracted from
- Cadmium transport in isolated enterocytes of freshwater rainbow trout: interactions with zinc and iron, effects of complexation with cysteine, and an ATPase-coupled efflux (2012), Comp. Biochem. Physiol. C, 155, 238-246.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| HCO3- | cellular Cd2+ uptake increases in the presence of HCO3- | Oncorhynchus mykiss |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | inhibits cellular Cd2+ uptake through a competitive interaction | Oncorhynchus mykiss | |
| additional information | pre-exposure to either 0.01 or 0.1 mM orthovanadate does not affect the cellular Cd2+ uptake rate. After 60 min efflux, approximately 40% and 20% of accumulated Cd2+ in the enterocytes is lost in the absence and presence of orthovanadate, respectively, when compared to 0 min. Pre-exposure to verapamil or lanthanum does not exhibit any effects on the cellular Cd2+ uptake rate | Oncorhynchus mykiss | |
| Zn2+ | inhibits cellular Cd2+ uptake through a competitive interaction | Oncorhynchus mykiss | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00086 | - |
Cd2+/out | pH and temperature not specified in the publication | Oncorhynchus mykiss | |
| 0.00169 | - |
Cd2+/out | in the presence of 2.5 mM Fe2+, pH and temperature not specified in the publication | Oncorhynchus mykiss | |
| 0.00193 | - |
Cd2+/out | in the presence of 0.01 mM Zn2+, pH and temperature not specified in the publication | Oncorhynchus mykiss | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | Cd2+ uptake is unaffected by Ca2+ | Oncorhynchus mykiss |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oncorhynchus mykiss | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| enterocyte | - |
Oncorhynchus mykiss | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Cd2+/out | - |
Oncorhynchus mykiss | ADP + phosphate + Cd2+/in | - |
? | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0098 | - |
pH and temperature not specified in the publication | Oncorhynchus mykiss | Zn2+ | |
| 2.5 | - |
pH and temperature not specified in the publication | Oncorhynchus mykiss | Fe2+ | |
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Release 2023.1 (January 2023)
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