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Literature summary for 7.2.2.2 extracted from

  • Schwartz, M.S.; Benci, J.L.; Selote, D.S.; Sharma, A.K.; Chen, A.G.; Dang, H.; Fares, H.; Vatamaniuk, O.K.
    Detoxification of multiple heavy metals by a half-molecule ABC transporter, HMT-1, and coelomocytes of Caenorhabditis elegans (2010), PLoS ONE, 5, e9564.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.2

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
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Caenorhabditis elegans G5EFD4
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Source Tissue

Source Tissue Comment Organism Textmining
coelomocyte
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 Caenorhabditis elegans
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coelomocyte phytochelatin synthase pcs-1 and hmt-1 are co-expressed in coelomocytes. Coelomocytes are essential mainly for detoxification of heavy metals, but not of oxidative stress, a by-product of heavy metal toxicity Caenorhabditis elegans
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intestine
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 Caenorhabditis elegans
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neuron head neurons Caenorhabditis elegans
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Synonyms

Synonyms Comment Organism
half-molecule ATP-binding cassette (ABC) transporter
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 Caenorhabditis elegans
HMT-1
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 Caenorhabditis elegans

General Information

General Information Comment Organism
malfunction hmt-1 deletion alleles of Caenorhabditis elegans are hypersensitive to Cd Caenorhabditis elegans
physiological function functional in vivo assays show that HMT-1 from Caenorhabditis elegans, functions distinctly from its Schizosaccharomyces pombe counterpart in that in addition to Cd it confers tolerance to arsenic and copper while acting independently of phytochelatin synthase Caenorhabditis elegans
physiological function in addition to Cd, HMT-1 confers tolerance to arsenic and copper while acting independently of phytochelatin synthase pcs-1 Caenorhabditis elegans