Cloned (Comment) | Organism |
---|---|
expression in Schizosaccharomyces pombe | Drosophila melanogaster |
phylogenetic analysis | Schizosaccharomyces pombe |
Protein Variants | Comment | Organism |
---|---|---|
additional information | heterologously expressed DmHMT-1 suppresses the Cd2+ hypersensitivity of Schizosaccharomyces pombe hmt-1 mutants and localizes to the vacuolar membrane but does not transport Cd-PCc, phenotype, overview | Drosophila melanogaster |
additional information | SpHMT-1-deficient cells are hypersensitive to Cd2+, but not to Hg2+ or As3+, heterologously expressed Drosophila melanogaster HMT-1 suppresses the Cd2+ hypersensitivity of Schizosaccharomyces pombe hmt-1 mutants and localizes to the vacuolar membrane but does not transport Cd-PCc, overview | Schizosaccharomyces pombe |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
vacuolar membrane | - |
Schizosaccharomyces pombe | 5774 | - |
vacuolar membrane | - |
Drosophila melanogaster | 5774 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
97900 | - |
x * 97900 | Drosophila melanogaster |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Cd2+/in | Drosophila melanogaster | ABC transporter, DmHMT-1, confers tolerance to cadmium. DmHMT-1 and its yeast homolog, SpHMT-1, are not essential for vacuolar phytochelatin sequestration | ADP + phosphate + Cd2+/out | - |
? | |
ATP + H2O + Cd2+/in | Schizosaccharomyces pombe | ABC transporter, HMT-1, confers tolerance to cadmium. HMT-1 is not essential for vacuolar phytochelatin sequestration. HMT-1 either does not transport Cd-PC complexes or is not the principal Cd-PC/apoPC transporter | ADP + phosphate + Cd2+/in | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | Q9VF20 | - |
- |
Schizosaccharomyces pombe | - |
wild-type strain YF01 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Cd2+/in | - |
Schizosaccharomyces pombe | ADP + phosphate + Cd2+/out | - |
? | |
ATP + H2O + Cd2+/in | - |
Drosophila melanogaster | ADP + phosphate + Cd2+/out | - |
? | |
ATP + H2O + Cd2+/in | ABC transporter, DmHMT-1, confers tolerance to cadmium. DmHMT-1 and its yeast homolog, SpHMT-1, are not essential for vacuolar phytochelatin sequestration | Drosophila melanogaster | ADP + phosphate + Cd2+/out | - |
? | |
ATP + H2O + Cd2+/in | ABC transporter, HMT-1, confers tolerance to cadmium. HMT-1 is not essential for vacuolar phytochelatin sequestration. HMT-1 either does not transport Cd-PC complexes or is not the principal Cd-PC/apoPC transporter | Schizosaccharomyces pombe | ADP + phosphate + Cd2+/in | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 97900 | Drosophila melanogaster |
Synonyms | Comment | Organism |
---|---|---|
heavy metal tolerance factor 1 | - |
Schizosaccharomyces pombe |
heavy metal tolerance factor 1 | - |
Drosophila melanogaster |
HMT-1 | - |
Schizosaccharomyces pombe |
HMT-1 | - |
Drosophila melanogaster |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Schizosaccharomyces pombe | |
ATP | - |
Drosophila melanogaster |