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Literature summary for 7.2.2.2 extracted from

  • Rebbeor, J.F.; Connolly, G.C.; Dumont, M.E.; Ballatori, N.
    ATP-dependent transport of reduced glutathione on YCF1, the yeast orthologue of mammalian multidrug resistance associated proteins (1998), J. Biol. Chem., 273, 33449-33454.
    View publication on PubMed
Search for more literature for 7.2.2.2

Cloned(Commentary)

Cloned (Comment) Organism
-
 Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
G756D substitution mutation, unable to complement the cadmium hypersensitivity of the introduced strain Saccharomyces cerevisiae
G756S substitution mutation, unable to complement the cadmium hypersensitivity of the introduced strain Saccharomyces cerevisiae
K669M substitution mutation, unable to complement the cadmium hypersensitivity of the introduced strain Saccharomyces cerevisiae
additional information deletion of F713, mutant protein not localized to the vacuole, no cadmium resistance Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
4',4'-diisothiocyanatostilbene-2',2'-disulfonic acid uptake of S-(2,4-dinitrophenyl)glutathione inhibited Saccharomyces cerevisiae
probenecid uptake of S-(2,4-dinitrophenyl)glutathione inhibited Saccharomyces cerevisiae
sulfinpyrazone uptake of S-(2,4-dinitrophenyl)glutathione inhibited Saccharomyces cerevisiae
vanadate uptake of S-(2,4-dinitrophenyl)glutathione inhibited Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
15
-
 glutathione in vesicles Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
tonoplast
-
 Saccharomyces cerevisiae
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
120000
-
 SDS-PAGE Saccharomyces cerevisiae
140000
-
 SDS-PAGE Saccharomyces cerevisiae
170000
-
 SDS-PAGE Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glutathione S-conjugates/cytoplasm + ATP + H2O Saccharomyces cerevisiae
-
 glutathione S-conjugates/vacuole + ADP + phosphate
-
 ?
glutathione/cytoplasm + ATP + H2O Saccharomyces cerevisiae
-
 glutathione/vacuole + ADP + phosphate
-
 ?
S-(2,4-dinitrophenyl)glutathione/cytoplasm + ATP + H2O Saccharomyces cerevisiae
-
 S-(2,4-dinitrophenyl)glutathione/vacuole + ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione S-conjugates/cytoplasm + ATP + H2O
-
 Saccharomyces cerevisiae glutathione S-conjugates/vacuole + ADP + phosphate
-
 ?
glutathione/cytoplasm + ATP + H2O
-
 Saccharomyces cerevisiae glutathione/vacuole + ADP + phosphate
-
 ?
S-(2,4-dinitrophenyl)glutathione/cytoplasm + ATP + H2O
-
 Saccharomyces cerevisiae S-(2,4-dinitrophenyl)glutathione/vacuole + ADP + phosphate
-
 ?