Application | Comment | Organism |
---|---|---|
additional information | binding and release steps of K+ and H+ in both principal conformations of the ion pump, E1 and P-E2, are electrogenic, whereas the conformation transitions do not contribute significantly to a charge movement wihtin the membrane dielectric | Sus scrofa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
SCH28080 | completely blocks enzyme activity | Sus scrofa |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | activates, with 0.11 mM as half saturating K+ concentration for both luminal binding sites, above 10 mM reduction of enzyme activity | Sus scrofa | |
Na+ | - |
Sus scrofa | |
NH4+ | - |
Sus scrofa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gastric mucosa | - |
Sus scrofa | - |
stomach | - |
Sus scrofa | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
2.383 | - |
in the presence of 2 mM K+, with ATP as substrate, at 37°C | Sus scrofa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + H+/in + K+/out | - |
Sus scrofa | ADP + phosphate + H+/out + K+/in | - |
? |
Synonyms | Comment | Organism |
---|---|---|
H,K-ATPase | - |
Sus scrofa |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.5 | 8.5 | at pH 6.5 30% and at pH 8.5 less than 1% of all binding sites are occupied by H+ ions | Sus scrofa |