Cloned (Comment) | Organism |
---|---|
efficient formation of the functional Atp1al1-betaHK complex in membranes of Sf-212-insect cells. Atp1al1-betaHK is a complex of the alpha-subunit of human nongastric H,K-ATPase with the gastric H,K-ATPase beta-subunit | Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile | - |
Oryctolagus cuniculus | |
Ouabain | K+ exhibits strong antagonism with the inhibitor | Oryctolagus cuniculus | |
SCH28080 | K+ exhibits strong antagonism with the inhibitor | Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + H+/in + K+/out | - |
Oryctolagus cuniculus | ADP + phosphate + H+/out + K+/in | - |
? | |
additional information | the Atp1al1-betaHK complex exhibits significant ATPase activity in nominally K+-free medium. The addition of K+ stimulates the ATPhydrolysis up to 3fold | Oryctolagus cuniculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
nongastric H,K-ATPase | - |
Oryctolagus cuniculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.064 | - |
Ouabain | pH 7.4, 37°C | Oryctolagus cuniculus | |
0.093 | - |
2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile | pH 7.4, 37°C | Oryctolagus cuniculus |