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Literature summary for 7.2.2.19 extracted from

  • Adams, G.; Tillekeratne, M.; Yu, C.; Pestov, N.B.; Modyanov, N.N.
    Catalytic function of nongastric H,K-ATPase expressed in Sf-21 insect cells (2001), Biochemistry, 40, 5765-5776.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
efficient formation of the functional Atp1al1-betaHK complex in membranes of Sf-212-insect cells. Atp1al1-betaHK is a complex of the alpha-subunit of human nongastric H,K-ATPase with the gastric H,K-ATPase beta-subunit Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile
-
Oryctolagus cuniculus
Ouabain K+ exhibits strong antagonism with the inhibitor Oryctolagus cuniculus
SCH28080 K+ exhibits strong antagonism with the inhibitor Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+/in + K+/out
-
Oryctolagus cuniculus ADP + phosphate + H+/out + K+/in
-
?
additional information the Atp1al1-betaHK complex exhibits significant ATPase activity in nominally K+-free medium. The addition of K+ stimulates the ATPhydrolysis up to 3fold Oryctolagus cuniculus ?
-
?

Synonyms

Synonyms Comment Organism
nongastric H,K-ATPase
-
Oryctolagus cuniculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.064
-
Ouabain pH 7.4, 37°C Oryctolagus cuniculus
0.093
-
2-methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile pH 7.4, 37°C Oryctolagus cuniculus