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Literature summary for 7.2.2.16 extracted from

  • Schultz-Hauser, G.; Koster, W.; Schwarz, H.; Braun, V.
    Iron(III) hydroxamate transport in Escherichia coli K-12: FhuB-mediated membrane association of the FhuC protein and negative complementation of fhuC mutants (1992), J. Bacteriol., 174, 2305-2311.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.16

Cloned(Commentary)

Cloned (Comment) Organism
fhuC, FhuC fhuB, FhuA fhuC, fhuACDB cloned and overexpressed Escherichia coli

Protein Variants

Protein Variants Comment Organism
D172E fhuC Escherichia coli
D172N fhuC Escherichia coli
K50E fhuC Escherichia coli
K50Q fhuC Escherichia coli
additional information fhuC, deletion from Ile180 to Asp207, no phenotypic suppression Escherichia coli
additional information fhuC, duplication from Gly23 to Asp177, no phenotypic suppression Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasmic membrane FhuC membrane associated, preferential in the presence of FhuB, detected by FhuC antibodies Escherichia coli
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + iron(III) hydroxamates/out Escherichia coli
-
 ADP + phosphate + iron(III) hydroxamates/in
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O + Fe3+-hydroxamate complex-[hydroxamate-binding protein][side 1] = ADP + phosphate + Fe3+-hydroxamate complex[side 2] + [hydroxamate-binding protein][side 1] the FhuC protein contains two ATP-binding domains Escherichia coli
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + iron(III) hydroxamates/out
-
 Escherichia coli ADP + phosphate + iron(III) hydroxamates/in
-
 ?

Subunits

Subunits Comment Organism
More ATP-transporter Escherichia coli