Literature summary for 7.2.2.15 extracted from

  • Gupta, A.; Matsui, K.; Lo, J.F.; Silver, S.
    Molecular basis for resistance to silver cations in Salmonella (1999), Nature Med., 5, 183-188.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
the gene is encoded by Ag+ resistance plasmid pMG101, the plasmid is transferred by conjugation to Escherichia coli, from which it is cloned Salmonella sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Ag+/in Salmonella sp. required for Ag+ resistance ADP + phosphate + Ag+/out
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?

Organism

Organism UniProt Comment Textmining
Salmonella sp.
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gene is encoded by Ag+ resistance plasmid pMG101
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Purification (Commentary)

Purification (Comment) Organism
gene is encoded by Ag+ resistance plasmid pMG101 Salmonella sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Ag+/in
-
Salmonella sp. ADP + phosphate + Ag+/out
-
?
ATP + H2O + Ag+/in required for Ag+ resistance Salmonella sp. ADP + phosphate + Ag+/out
-
?

Subunits

Subunits Comment Organism
More enzyme of the heavy-metal resistance efflux P-type ATPase family. The enzyme has a conserved aspartyl residues that is phosphorylated during the enzyme cycle, the ATP-binding region, the Thr-Gly-Glu-Ser phosphatase determinant, the Cys-Pro-Cys in the predicted sixth transmembrane alpha-helical region, and the His-Pro in the large aspartyl kinase domain between the phosphorylation site and the ATP binding region Salmonella sp.

Synonyms

Synonyms Comment Organism
SilP
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Salmonella sp.