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Literature summary for 7.2.2.14 extracted from
- Tributyltin (TBT) inhibition of oligomycin-sensitive Mg-ATPase activity in mussel mitochondria (2008), Toxicol. in Vitro, 22, 827-836.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| tributyltin | TBT, one of the most toxic lipophilic aquatic pollutants. Maximal inhibition of 82% in the gills and 74% in the mantle at 0.00062 mM TBT, non-cooperative inhibition kinetics and a non-competitive mechanism with respect to ATP substrate, via formation of a TBT-Mg-ATPase complex, apparently more stable in the gills than in the mantle | Mytilus galloprovincialis |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics | Mytilus galloprovincialis | |
| 1.5 | - |
ATP | pH 9.0, 30°C, gill enzyme | Mytilus galloprovincialis | |
| 2.8 | - |
ATP | pH 9.0, 30°C, mantle enzyme | Mytilus galloprovincialis | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Mytilus galloprovincialis | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Mg2+/out | Mytilus galloprovincialis | - |
ADP + phosphate + Mg2+/in | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mytilus galloprovincialis | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| gill | - |
Mytilus galloprovincialis | - |
| mantle | - |
Mytilus galloprovincialis | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.25 | - |
gill enzyme | Mytilus galloprovincialis |
| 0.5 | - |
mantle enzyme | Mytilus galloprovincialis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Mg2+/out | - |
Mytilus galloprovincialis | ADP + phosphate + Mg2+/in | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| oligomycin-sensitive Mg-ATPase | - |
Mytilus galloprovincialis |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Mytilus galloprovincialis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9 | - |
assay at | Mytilus galloprovincialis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mytilus galloprovincialis | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | inhibition kinetics, the inhibition by tributyltin follows a noncooperative kinetics in both tissues, gill and mantle | Mytilus galloprovincialis | |
| 0.12 | 0.13 | tributyltin | pH 9.0, 30°C, mantle enzyme | Mytilus galloprovincialis | |
| 0.13 | 0.17 | tributyltin | pH 9.0, 30°C, gill enzymem | Mytilus galloprovincialis | |
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