Literature summary for 7.2.2.14 extracted from

Liapi, C.; Zarros, A.; Theocharis, S.; Al-Humadi, H.; Anifantaki, F.; Gkrouzman, E.; Mellios, Z.; Skandali, N.; Tsakiris, S.
The neuroprotective role of L-cysteine towards the effects of short-term exposure to lanthanum on the adult rat brain antioxidant status and the activities of acetylcholinesterase, (Na+,K+)- and Mg2+-ATPase (2009), Biometals, 22, 329-335.

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Inhibitors

Inhibitors	Comment	Organism	Structure
cysteine	inhibits the Mg2+-ATPase activity by 15%, in addition with lanthanum by 25%	Rattus norvegicus
lanthanum	inhibits the Mg2+-ATPase activity by 8%, not reversible but increased by Cys co-administration to 25% inhibition	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Rattus norvegicus	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + Mg2+/out	Rattus norvegicus	-	ADP + phosphate + Mg2+/in	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male Wistar rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.09	-	brain Mg2+-ATPase in presence of Cys and lanthanum	Rattus norvegicus
0.121	-	brain Mg2+-ATPase	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + Mg2+/out	-	Rattus norvegicus	ADP + phosphate + Mg2+/in	-	?

Synonyms

Synonyms	Comment	Organism
Mg2+-ATPase	-	Rattus norvegicus
Mg2+-dependent ATPase	-	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Rattus norvegicus

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Release 2023.1 (January 2023)