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Literature summary for 7.2.2.14 extracted from

  • Chamnongpol, S.; Groisman, E.A.
    Mg2+ homeostasis and avoidance of metal toxicity (2002), Mol. Microbiol., 44, 561-571.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Salmonella enterica
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serovar typhimurium
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Oxidation Stability

Oxidation Stability Organism
Mutants defective in phoP or in both mgtA and mgtB are hypersensitive to oxidative stress-dependent Fe(II)-mediated killing Salmonella enterica

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O + Mg2+[side 1] = ADP + phosphate + Mg2+[side 2] Three transporters mediate Mg2+-uptake, the P-type ATPases MgtA and MgtB, whose expression is transcriptionally induced in low Mg2+ by the Mg2+-regulated PhoP/PhoQ two-component system, and CorA, whose transcription is regulated neither by the levels of Mg2+ nor by the PhoP/PhoQ system. CorA modulates its activity in response to the presence of PhoP-regulated gene products. Salmonella enterica