Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 7.2.2.13 extracted from

  • Kim, H.; Lim, B.; Kim, B.; Lee, Y.
    Effects of heavy metals on transcription and enzyme activity of Na+/K+-ATPase in the monogonont rotifer, Brachionus koreanus (2016), Toxicol. Environ. Health Sci., 8, 128-134 .
No PubMed abstract available
Search for more literature for 7.2.2.13

Metals/Ions

Metals/Ions Comment Organism Structure
Cd2+ a significant increase in enzyme activity is observed after exposure to Cd2+ in a concentration-dependent manner (about 3.5fold increase in activity at 7.5 mg/l, about 5.8fold increase in activity at 15 mg/l) Brachionus koreanus
Pb2+ a significant increase in enzyme activity is observed after exposure to Pb2+ in a concentration-dependent manner (about 2.5fold increase in activity at 0.1 mg/l, about 4.5fold increase in activity at 1 mg/l) Brachionus koreanus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Na+[side 1] + K+[side 2] Brachionus koreanus
-
 ADP + phosphate + Na+[side 2] + K+[side 1]
-
 ?

Organism

Organism UniProt Comment Textmining
Brachionus koreanus
-
 S type
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Na+[side 1] + K+[side 2]
-
 Brachionus koreanus ADP + phosphate + Na+[side 2] + K+[side 1]
-
 ?

Synonyms

Synonyms Comment Organism
Na+/K+-ATPase
-
 Brachionus koreanus

Expression

Organism Comment Expression
Brachionus koreanus the enzyme mRNA level is significantly downregulated in Pb2+-exposed Brachionus koreanus down
Brachionus koreanus the enzyme mRNA level is significantly upregulated in Cd2+-exposed Brachionus koreanus up

General Information

General Information Comment Organism
physiological function the enzyme is involved in cellular homeostasis in response to heavy metal exposure Brachionus koreanus