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Literature summary for 7.2.2.13 extracted from

  • Sampaio, L.S.; Iannotti, F.A.; Veneziani, L.; Borelli-Torres, R.T.; De Maio, F.; Piscitelli, F.; Reis, R.A.M.; Di Marzo, V.; Einicker-Lamas, M.
    Experimental ischemia/reperfusion model impairs endocannabinoid signaling and Na+/K+ ATPase expression and activity in kidney proximal tubule cells (2018), Biochem. Pharmacol., 154, 482-491 .
    View publication on PubMed
Search for more literature for 7.2.2.13

Inhibitors

Inhibitors Comment Organism Structure
Ouabain specific inhibitor Rattus norvegicus
Ouabain specific inhibitor Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
basolateral plasma membrane
-
 Rattus norvegicus 16323
-
basolateral plasma membrane
-
 Sus scrofa 16323
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Na+[side 1] + K+[side 2] Rattus norvegicus
-
 ADP + phosphate + Na+[side 2] + K+[side 1]
-
 ?
ATP + H2O + Na+[side 1] + K+[side 2] Sus scrofa
-
 ADP + phosphate + Na+[side 2] + K+[side 1]
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus norvegicus
-
LLC-PK1 cell
-
 Sus scrofa
-
renal proximal tubule cell
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Na+[side 1] + K+[side 2]
-
 Rattus norvegicus ADP + phosphate + Na+[side 2] + K+[side 1]
-
 ?
ATP + H2O + Na+[side 1] + K+[side 2]
-
 Sus scrofa ADP + phosphate + Na+[side 2] + K+[side 1]
-
 ?

Subunits

Subunits Comment Organism
? x * 110000, SDS-PAGE Rattus norvegicus
? x * 110000, SDS-PAGE Sus scrofa

Synonyms

Synonyms Comment Organism
Na+/K+ ATPase
-
 Rattus norvegicus
Na+/K+ ATPase
-
 Sus scrofa

Expression

Organism Comment Expression
Rattus norvegicus the enzyme is down-regulated following renal ischemia and reperfusion down
Sus scrofa the enzyme is down-regulated following renal ischemia and reperfusion down

General Information

General Information Comment Organism
physiological function main enzyme responsible for Na+ reabsorption through the renal epithelium Rattus norvegicus
physiological function main enzyme responsible for Na+ reabsorption through the renal epithelium Sus scrofa