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Literature summary for 7.2.2.13 extracted from

  • Chen, X.L.; Wee, N.L.; Hiong, K.C.; Ong, J.L.; Chng, Y.R.; Ching, B.; Wong, W.P.; Chew, S.F.; Ip, Y.K.
    Properties and expression of Na+/K+-ATPase alpha-subunit isoforms in the brain of the swamp eel, Monopterus albus, which has unusually high brain ammonia tolerance (2013), PLoS ONE, 8, e84298.
    View publication on PubMedView publication on EuropePMC
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Metals/Ions

Metals/Ions Comment Organism Structure
K+ activates Monopterus albus
NH4+ NH4+ can substitute for K+ to activate the enzyme Monopterus albus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
113000
-
 x * 113000, alpha subunit, calculated from amino acid sequence Monopterus albus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Na+/in + K+/out Monopterus albus
-
 ADP + phosphate + Na+/out + K+/in
-
 ?

Organism

Organism UniProt Comment Textmining
Monopterus albus T2B3R7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Monopterus albus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Na+/in + K+/out
-
 Monopterus albus ADP + phosphate + Na+/out + K+/in
-
 ?

Subunits

Subunits Comment Organism
? x * 113000, alpha subunit, calculated from amino acid sequence Monopterus albus

Synonyms

Synonyms Comment Organism
Na+/K+-ATPase
-
 Monopterus albus
NKA
-
 Monopterus albus
nkaalpha1 isoform Monopterus albus
nkaalpha3a isoform Monopterus albus
nkaalpha3b isoform Monopterus albus

Expression

Organism Comment Expression
Monopterus albus there is down-regulation of mRNA expression of all three enzyme nkaalpha isoforms and the overall protein abundance in response to ammonia exposure down