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Literature summary for 7.2.2.13 extracted from

  • Sapia, L.; Palomeque, J.; Mattiazzi, A.; Petroff, M.V.
    Na+/K+-ATPase inhibition by ouabain induces CaMKII-dependent apoptosis in adult rat cardiac myocytes (2010), J. Mol. Cell. Cardiol., 49, 459-468.
    View publication on PubMed
Search for more literature for 7.2.2.13

Application

Application Comment Organism
medicine the positive inotropic effect produced by Na+/K+-ATPase inhibition is used for the treatment of heart failure Mus musculus
medicine the positive inotropic effect produced by Na+/K+-ATPase inhibition is used for the treatment of heart failure Rattus norvegicus
medicine the positive inotropic effect produced by Na+/K+-ATPase inhibition is used for the treatment of heart failure Felis catus

Inhibitors

Inhibitors Comment Organism Structure
Ouabain ouabain triggers an apoptotic cascade that involves NCX and CaMKII as a downstream effector. Ouabain simultaneously activates an antiapoptotic cascade involving PI3K/AKT which is however, insufficient to completely repress apoptosis. The NCX inhibitor KB-R7943 and by the CaMKII inhibitors, KN93 and AIP prevent ouabain-induced apoptosis without affecting inotropy. Ouabain produces in the cat at 25 nM a 43% decrease in cell viability due to apoptosis and necrosis Felis catus
Ouabain ouabain triggers an apoptotic cascade that involves NCX and CaMKII as a downstream effector. Ouabain simultaneously activates an antiapoptotic cascade involving PI3K/AKT which is however, insufficient to completely repress apoptosis.The NCX inhibitor KB-R7943 and by the CaMKII inhibitors, KN93 and AIP prevent ouabain-induced apoptosis without affecting inotropy Mus musculus
Ouabain ouabain triggers an apoptotic cascade that involves NCX and CaMKII as a downstream effector. Ouabain simultaneously activates an antiapoptotic cascade involving PI3K/AKT which is however, insufficient to completely repress apoptosis. The NCX inhibitor KB-R7943 and by the CaMKII inhibitors, KN93 and AIP prevent ouabain-induced apoptosis without affecting inotropy. Ouabain produces in the rat at 0.002 mM a 43% decrease in cell viability due to apoptosis and necrosis Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-
membrane
-
 Rattus norvegicus 16020
-
membrane
-
 Felis catus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Na+/in + K+/out Mus musculus
-
 ADP + phosphate + Na+/out + K+/in
-
 ?
ATP + H2O + Na+/in + K+/out Rattus norvegicus
-
 ADP + phosphate + Na+/out + K+/in
-
 ?
ATP + H2O + Na+/in + K+/out Felis catus
-
 ADP + phosphate + Na+/out + K+/in
-
 ?

Organism

Organism UniProt Comment Textmining
Felis catus
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
 Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiac myocyte
-
 Mus musculus
-
cardiac myocyte
-
 Rattus norvegicus
-
cardiac myocyte
-
 Felis catus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Na+/in + K+/out
-
 Mus musculus ADP + phosphate + Na+/out + K+/in
-
 ?
ATP + H2O + Na+/in + K+/out
-
 Rattus norvegicus ADP + phosphate + Na+/out + K+/in
-
 ?
ATP + H2O + Na+/in + K+/out
-
 Felis catus ADP + phosphate + Na+/out + K+/in
-
 ?

Synonyms

Synonyms Comment Organism
Na+/K+-ATPase
-
 Mus musculus
Na+/K+-ATPase
-
 Rattus norvegicus
Na+/K+-ATPase
-
 Felis catus

General Information

General Information Comment Organism
additional information Na+,K+-ATPase inhibitor ouabain triggers an apoptotic cascade that involves NCX and CaMKII as a downstream effector. Ouabain simultaneously activates an antiapoptotic cascade involving PI3K/AKT which is however, insufficient to completely repress apoptosis. KN93 prevents ouabain-induced apoptosis without affecting inotropy Mus musculus
additional information Na+,K+-ATPase inhibitor ouabain triggers an apoptotic cascade that involves NCX and CaMKII as a downstream effector. Ouabain simultaneously activates an antiapoptotic cascade involving PI3K/AKT which is however, insufficient to completely repress apoptosis. KN93 prevents ouabain-induced apoptosis without affecting inotropy Rattus norvegicus
additional information Na+,K+-ATPase inhibitor ouabain triggers an apoptotic cascade that involves NCX and CaMKII as a downstream effector. Ouabain simultaneously activates an antiapoptotic cascade involving PI3K/AKT which is however, insufficient to completely repress apoptosis. KN93 prevents ouabain-induced apoptosis without affecting inotropy Felis catus