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Literature summary for 7.2.2.13 extracted from

  • Chen, R.J.; Chung, T.Y.; Li, F.Y.; Yang, W.H.; Jinn, T.R.; Tzen, J.T.
    Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na+/K+ -ATPase (2010), Acta Pharmacol. Sin., 31, 696-702.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.13

Inhibitors

Inhibitors Comment Organism Structure
astragaloside III from dried roots of Astragalus membraneceus or var. mongholicus Sus scrofa
bufalin from dried venom of Bufo gargarizans or Bufo bufo melanostictus Sus scrofa
cholic acid from dried bile of Ursus arctos or Selenarctos thibetanus Sus scrofa
ginsenoside Rh2 from dried roots of Panax ginseng or Panax notoginseng Sus scrofa
glycyrrhizin from roots of Glycyrrhiza uralensis , Glycyrrhiza inflata, or Glycyrrhiza glabra Sus scrofa
jujuboside B from mature seeds of Ziziphus jujube var. spinosa Sus scrofa
additional information molecular docking and modelling, and inhibitory potencies of steroid-like compounds from Chinese medicinal products, used for promoting the blood circulation, with Na+,K+-ATPase, overview Sus scrofa
oleanolic acid from whole plant of Prunella vulgaris with dried flowers Sus scrofa
Ouabain
-
 Sus scrofa
polygalacic acid from dried roots of Platycodon grandiflorum Sus scrofa
saikosaponin A from dried roots of Bupleurum chinense or Bupleurum scorzonerifolium Sus scrofa
sarsasapogenin from dried roots of Anemarrhena asphodeloides Sus scrofa
ursolic acid from whole plant of Prunella vulgaris with dried flowers Sus scrofa

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Na+/in + K+/out Sus scrofa
-
 ADP + phosphate + Na+/out + K+/in
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain cerebral cortex Sus scrofa
-
commercial preparation
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Na+/in + K+/out
-
 Sus scrofa ADP + phosphate + Na+/out + K+/in
-
 ?

Synonyms

Synonyms Comment Organism
Na+/K+ -ATPase
-
 Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 assay at room temperature Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
 assay at Sus scrofa