Crystallization (Comment) | Organism |
---|---|
refinement to 9-11 A | Mammalia |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ouabain | interaction is dependent on the conformation and phosphorylation state of the protein | Mammalia |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
7000 | - |
gamma subunit: 6500-7500 Da, identified in kidney tissue | Mammalia |
35000 | - |
beta subunit | Mammalia |
112000 | - |
alpha subunit | Mammalia |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + phosphate + Na+/out | Mammalia | each cycle extrudes 3 Na+ from the cell and moves 2 K+ into the cell with utilization of 1 ATP | ATP + H2O + Na+/in | - |
r | |
ATP + H2O + K+/in | Mammalia | - |
ADP + phosphate + K+/out | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mammalia | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | beta subunit | Mammalia |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + phosphate + Na+/out | - |
Mammalia | ATP + H2O + Na+/in | - |
r | |
ADP + phosphate + Na+/out | each cycle extrudes 3 Na+ from the cell and moves 2 K+ into the cell with utilization of 1 ATP | Mammalia | ATP + H2O + Na+/in | - |
r | |
ATP + H2O + K+/in | - |
Mammalia | ADP + phosphate + K+/out | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | alphabeta, minimal functional unit, aggrgation of protomeric units is a common observation | Mammalia |
trimer | alphabetagamma | Mammalia |
Synonyms | Comment | Organism |
---|---|---|
Na(+)-K(+)-exchanging ATPase | - |
Mammalia |
Na+,K+-adenosine triphosphatase | - |
Mammalia |
Na+,K+-ATPase | - |
Mammalia |
Na+,K+-pump | - |
Mammalia |
Na,K-Pump | - |
Mammalia |