Literature summary for 7.2.2.13 extracted from

Periyasamy, S.M.; Liu, J.; Tanta, F.; Kabak, B.; Wakefield, B.; Malhotra, D.; Kennedy, D.J.; Nadoor, A.; Fedorova, O.V.; Gunning, W.; Xie, Z.; Bagrov, A.Y.; Shapiro, J.I.
Salt loading induces redistribution of the plasmalemmal Na/K-ATPase in proximal tubule cells (2005), Kidney Int., 67, 1868-1877.

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Inhibitors

Inhibitors	Comment	Organism	Structure
marinobufagenin	-	Rattus norvegicus
Ouabain	-	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plasmalemma	-	Rattus norvegicus	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ADP + phosphate + Na+/out	Rattus norvegicus	-	ATP + H2O + Na+/in	-	?
ATP + H2O + K+/in	Rattus norvegicus	-	ADP + phosphate + K+/out	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	Sprague-Dawley rat	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
proximal tubule	-	Rattus norvegicus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.085	-	high salt diet	Rattus norvegicus
0.165	-	high normal diet	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ADP + phosphate + Na+/out	-	Rattus norvegicus	ATP + H2O + Na+/in	-	?
ATP + H2O + K+/in	-	Rattus norvegicus	ADP + phosphate + K+/out	-	?

Synonyms

Synonyms	Comment	Organism
Na/K-ATPase	-	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	activity assay	Rattus norvegicus

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Release 2023.1 (January 2023)