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Literature summary for 7.2.2.13 extracted from

  • Wang Xue, Q.; Yu Shan, P.
    Novel regulation of Na, K-ATPase by Src tyrosine kinases in cortical neurons (2005), J. Neurochem., 93, 1515-1523.
    View publication on PubMed
Search for more literature for 7.2.2.13

Activating Compound

Activating Compound Comment Organism Structure
dephostatin
-
 Mus musculus
K+ extracellular Mus musculus
Lyn kinase Lyn kinase directly binds to the Na+,K+-ATPase alpha3 subunit for regulation of activity Mus musculus
Yes kinase regulator of the Na+,K+-ATPase activity Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
genistein tyrosine kinase inhibitor, block phosphorylation of alpha-subunit of the Na+,K+-ATPase Mus musculus
herbimycin A tyrosine kinase inhibitor, block phosphorylation of alpha-subunit of the Na+,K+-ATPase Mus musculus
lavendustin A tyrosine kinase inhibitor, block phosphorylation of alpha-subunit of the Na+,K+-ATPase Mus musculus
Lyn kinase Lyn kinase directly binds to the Na+,K+-ATPase alpha3 subunit for regulation of activity Mus musculus
Ouabain
-
 Mus musculus
PP1 Src kinase inhibitor Mus musculus
strophanthidin tyrosine kinase inhibitor, block phosphorylation of alpha-subunit of the Na+,K+-ATPase Mus musculus
Yes kinase regulator of the Na+,K+-ATPase activity Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + phosphate + Na+/out Mus musculus each cycle extrudes 3 Na+ from the cell and moves 2 K+ into the cell with utilization of 1 ATP ATP + H2O + Na+/in
-
 ?
ATP + H2O + K+/in Mus musculus
-
 ADP + phosphate + K+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphate + Na+/out
-
 Mus musculus ATP + H2O + Na+/in
-
 ?
ADP + phosphate + Na+/out each cycle extrudes 3 Na+ from the cell and moves 2 K+ into the cell with utilization of 1 ATP Mus musculus ATP + H2O + Na+/in
-
 ?
ATP + H2O + K+/in
-
 Mus musculus ADP + phosphate + K+/out
-
 ?

Synonyms

Synonyms Comment Organism
Na+,K+-ATPase
-
 Mus musculus
Na+,K+-pump
-
 Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.076
-
 strophanthidin IC50 Mus musculus