Literature summary for 7.2.2.13 extracted from

Peluffo, R.D.; Arguello, J.M.; Berlin, J.R.
The role of Na,K-ATPase alpha subunit serine 775 and glutamate 779 in determining the extracellular K+ and membrane potential-dependent properties of the Na,K-pump (2000), J. Gen. Physiol., 116, 47-59.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in HeLa cells	Ovis aries

Protein Variants

Protein Variants	Comment	Organism
E779A	15fold increase in K+ concentration that half-maximally activates Na,K-pump current at 0 mV in extracellular Na+-free solutions	Ovis aries
N122D	membrane potential and K+ dependence similar to wild-type Na,K-ATPase	Ovis aries
Q111R	membrane potential and K+ dependence similar to wild-type Na,K-ATPase	Ovis aries
S775A	155fold increase in K+ concentration that half-maximally activates Na,K-pump current at 0 mV in extracellular Na+-free solutions	Ovis aries

Organism

Organism	UniProt	Comment	Textmining
Ovis aries	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + Na+/in + K+/out	-	Ovis aries	ADP + phosphate + Na+/out + K+/in	-	?

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Release 2023.1 (January 2023)