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Literature summary for 7.2.2.12 extracted from

  • Eren, E.; Argueello, J.M.
    Arabidopsis HMA2, a divalent heavy metal-transporting PIB-type ATPase, is involved in cytoplasmic Zn2+ homeostasis (2004), Plant Physiol., 136, 3712-3723.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Saccharomyces cerevisiae Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Zn2+/in Arabidopsis thaliana HMA2 is responsible for Zn2+ efflux from the cells and is required for maintaining low cytoplasmic Zn2+ levels and normal Zn2+ homeostasis ADP + phosphate + Zn2+/out
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Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q9SZW4 ecotype Columbia
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cd2+/in 97% of the activity with Zn2+ Arabidopsis thaliana ADP + phosphate + Cd2+/out
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 ?
ATP + H2O + Co2+/in 45% of the activity with Zn2+ Arabidopsis thaliana ADP + phosphate + Co2+/out
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 ?
ATP + H2O + Cu2+/in about 40% of the activity with Zn2+ Arabidopsis thaliana ADP + phosphate + Cu2+/out
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 ?
ATP + H2O + Ni2+/in 45% of the activity with Zn2+ Arabidopsis thaliana ADP + phosphate + Ni2+/out
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 ?
ATP + H2O + Pb2+/in about 50% of the activity with Zn2+ Arabidopsis thaliana ADP + phosphate + Pb2+/out
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 ?
ATP + H2O + Zn2+/in
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 Arabidopsis thaliana ADP + phosphate + Zn2+/out
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 ?
ATP + H2O + Zn2+/in HMA2 is responsible for Zn2+ efflux from the cells and is required for maintaining low cytoplasmic Zn2+ levels and normal Zn2+ homeostasis Arabidopsis thaliana ADP + phosphate + Zn2+/out
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 ?

Synonyms

Synonyms Comment Organism
HMA2
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 Arabidopsis thaliana